S5
4-Wheel or All-Wheel Drive · Manual 6-spd · Subcompact Cars
- MPG combined
- 16
- City / highway
- 14 / 21
- Engine
- 4.2L 8-cyl
- Fuel
- Premium
- Annual fuel cost
- $5,150
- Tailpipe CO₂
- 555 g/mi

The Audi S5 has been sold in the US from 2008 to 2027, in 20 model years covered here. The 2027 line-up has 1 trim with 23 MPG combined.
4-Wheel or All-Wheel Drive · Manual 6-spd · Subcompact Cars
4-Wheel or All-Wheel Drive · Automatic (S6) · Subcompact Cars
Source: U.S. EPA / DOE fueleconomy.gov. Annual fuel cost is the EPA estimate for 15,000 miles a year at national average fuel and electricity prices.